I recently had a brief conversation with James Shelley (A writer I love to read and am wary of sounding creepily sycophantic of) on Twitter about Twitter. We're both users of Tweetbot, and have a preference in common when it comes to this choice.
Lists are a standard part of Twitter and a feature of most Twitter clients. The difference in Tweetbot is that it allows you to exchange your primary timeline for any of your own public of private lists, or lists that you are subscribed to. This gives you a lot more flexibility in how you approach your feed. You can very easily maintain tight control of what you are exposed to at any one time, two taps can switch you from seeing everyone you follow to seeing a feed with just close friends, or just those Twitter accounts pertaining to a favourite subject.
Using lists in this way was something I started to do, but never quite organised to the point of everyday practicality. The clear advantage is that I can freely follow as many people as I choose to, and maintain a private list to use as my primary feed. If the list is private, nobody knows if they're on one or more lists, and I can keep the number of active 'timeline' contributors to a sane level; effectively prioritising whom I read as a matter of course, and those individuals, companies or other entities that I do not wish to read all the time.
Bluntly put, I can be interested in what you have to say, but not so interested that I read every comment you make. It's liberating in a sense, as we always feel obliged to reciprocally connect to friends regardless of medium - and so we should (within reason), voluntarily reciprocal connection is the definition of a healthy community.
I'm going to set aside a half hour soon to build my lists and organise the accounts I follow, and take control of my Twitter intake.